A new nanoscale transdermal drug delivery system: oil body-linked oleosin-hEGF improves skin regeneration to accelerate wound healing
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چکیده
منابع مشابه
Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System that Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice
Recombinant human fibroblast growth factor 10 (rhFGF-10) is frequently used to treat patients with skin injuries. It can also promote hair growth. However, the effective application of rhFGF-10 is limited because of its poor stability and transdermal absorption. In this study, polymerase chain reaction (PCR) and Southern blotting were used to identify transgenic safflowers carrying a gene encod...
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Objective(s): This study aimed to find the effects of silver nanoparticles (Ag-NPs) (40 nm) on skin wound healing in mice Mus musculus when innate immune system has been suppressed.Materials and Methods: A group of 50 BALB/c mice of about 8 weeks (weighting 24.2±3.0 g) were randomly divided into two groups: Ag-NPs and control group, each with 25 mice. Once a day at the same time, a volume of 50...
متن کاملCalcium-Based Nanoparticles Accelerate Skin Wound Healing
INTRODUCTION Nanoparticles (NPs) are small entities that consist of a hydroxyapatite core, which can bind ions, proteins, and other organic molecules from the surrounding environment. These small conglomerations can influence environmental calcium levels and have the potential to modulate calcium homeostasis in vivo. Nanoparticles have been associated with various calcium-mediated disease proce...
متن کاملTransdermal sustained-delivery oxygen improves epithelial healing in a rabbit ear wound model.
HYPOTHESIS Transdermal sustained-delivery oxygen therapy improves wound healing. DESIGN Experimental study using a well-established rabbit ear model for acute wound healing. SETTING Wound-healing research laboratory in a university center. METHODS Four full-thickness 7-mm punch wounds were created on each ear of young, female New Zealand white rabbits. Treated ears received transdermal su...
متن کاملTransdermal drug delivery systems: skin perturbation devices.
Human skin serves a protective function by imposing physicochemical limitations to the type of permeant that can traverse the barrier. For a drug to be delivered passively via the skin it needs to have a suitable lipophilicity and a molecular weight < 500 Da. The number of commercially available products based on transdermal or dermal delivery has been limited by these requirements. In recent y...
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ژورنال
عنوان ژورنال: Journal of Nanobiotechnology
سال: 2018
ISSN: 1477-3155
DOI: 10.1186/s12951-018-0387-5